Despite the pressing need for innovation across the health journey, it can be incredibly difficult to embed innovation and achieve successful change within complex health systems. In this session, we’ll explore the opportunities and challenges for implementing user-centred health system and technology innovation. Using case studies and bringing real-world experience from diverse health care settings, specific strategies for achieving successful innovation will be highlighted in the following key areas. Engaging and empowering change with health system users and stakeholders. Effective co-design, user research, and iterative development. Clinically informed health technology product design and implementation.