This interdisciplinary workshop will bring together the unique knowledge of health care challenges from front-line users in diverse health care settings, along with the user-centered design expertise of collaborators at University of London Goldsmiths Department of Computing, UX Engineering Programme. We will first present examples of key pain points for clinicians, staff, and patients where user experience engineering and human-centered design principles were used to improve the care experience. Using these examples to highlight key learning and success factors, we will then break out into a hands-on session where participants can work together in small groups to tackle real-world health design challenges. Some examples of potential case studies for this session drawing from experience include: integration of HIV and substance use care in China, improving chronic care for a rural population in Rwanda, developing integrated systems and technology for improving proactive cancer screening and diabetes care for populations in the US and UK, and integrating mental health and primary care on the front lines.